1-aminoacetamidopyrroles and 1-amino acetamido-2-(substituted) p

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548518, 548527, 548530, 548531, 548532, 548534, 548537, 548539, 548540, 548543, 548550, 548551, 548556, 548562, A61K 3140, C07D207335

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active

056059256

ABSTRACT:
There are disclosed 1-aminoacetamidopyrroles and 1-amino-2-(substituted)pyrroles and related compounds of the formula ##STR1## wherein all substituents are defined herein, which are useful as glycine partial agonists and for the enhancement of learning and memory and for the treatment of memory dysfunctions associated with neurodegenerative disorders and are thus indicated in the treatment of Alzheimer's disease and other senile dementias.

REFERENCES:
patent: 4517195 (1985-05-01), Effland et al.
patent: 4588727 (1986-05-01), Effland et al.
CA 103:37509u Pyrrolo [1,2-6][1,2,5] Triazepines, Effland et al., p. 518, 1985.
CA 113:78430m Preparation . . . Drugs. Effland et al., p. 789, 1990.
CA 121:280539z Preparation . . . Drugs. Martin et al. p. 1022, 1994.
CA 112:1785311t Heterocyclization . . . Hydrate. Gadzhilly et al., p. 725, 1990.
CA 115:207401v ESR Spectroscopy . . . Cations. Avilla et al., p. 964, 1991.
CA 120:655706 Organic . . . Generation. Kawamonzen et al. p. 800, 1994.

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