1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-hete

Details 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-hete 1-Amino (or substituted amino)-1,4-dihydro-4-oxo-6-fluoro-7-hete

1983-02-14

1985-02-12

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514222, 514233, 514236, 514212, 514312, 544 586, 544128, 544363, 546156, 2602444, A61K 3147, C07D40104, C07D41304, C07D41704

Patent

active

044990910

ABSTRACT:
Novel 1-R-1,4-dihydro-4-oxo-6-fluoro-7-(Z.dbd.N--)-quinolinecarboxylic acids and esters thereof, where R is amino, lower-alkylamino, 2-propenylamino or di-lower-alkylamino, R" is hydrogen or lower-alkyl, and Z.dbd.N is a heterocyclic group, useful as antibacterial agents, are prepared by reacting the corresponding 7-chloroquinoline derivatives with the appropriate heterocyclic compound, Z.dbd.NH. A preferred group of compounds are those where Z.dbd.N is 1-piperazinyl or 4-lower-alkyl-1-piperazinyl.

REFERENCES:
patent: 4146719 (1979-03-01), Irikura
patent: 4284629 (1981-08-01), Grohe et al.
patent: 4292317 (1981-09-01), Pesson

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