1-amino-2-(substituted)pyrroles and related compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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Details

548518, 548539, 548540, 548557, C07D40306

Patent

active

055764460

ABSTRACT:
There are disclosed 1-aminoacetamidopyrroles and 1-amino-2-(substituted)pyrroles and related compounds of the formula ##STR1## wherein all substituents are defined herein, which are useful as glycine partial agonists and for the enhancement of learning and memory and for treatment of memory dysfunctions associated with neurodegenerative disorders and are thus indicated in the treatment of Alzheimer's disease and other senile dementias.

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CA103: 37509u Pyrrolo (1,2,-b)(1,2,5)trazepines. Effland et al., p. 518, 1985.
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CA121: 280539z Preparation . . . drugs. Martin et al, p. 1022, 1994.
CA112: 178531t Heterocyclization . . . hydrate. Gadzhily et al., p. 725, 1990.
CA115: 207401v ESR spectroscopy . . . cations. Avila, et al., p. 764, 1991.
CA120: 65570b Organic generation Kawamonzen et al., p. 800, 1994.
Tetrahedron Letters, vol. 29, No. 38, pp. 4823-4826, 1988 Jacobi, P. A. "A Novel Synthesis of Pyrromethenones".

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