1-.alpha.-hydroxylase materials and methods

Details 1-.alpha.-hydroxylase materials and methods 1-.alpha.-hydroxylase materials and methods

1997-08-06

2000-08-01

Achutamurthy, Ponnathapu

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435 691, 435189, 4352523, 4353201, 435455, 514 44, 536 235, 536 245, 800 8, 800 9, 800 18, C12N 1512, C12N 1553, C12N 1585, C12N 1590

Patent

active

060968761

ABSTRACT:
The invention is directed to polynucleotides encoding all or a fragment of the P450 moiety of vitamin D1 .alpha.-Hydrdoxylase and polypeptides encoded thereby. It encompasses antibodies to the polynucleotides and hybridizing polynucleotides. The polynucleotides and polypeptides are used in methods of diagnosing and treating vitamin D-related disorders and of producing vitamin D metabolites. The invention also encompasses expression vectors and animal cells comprising the polynucleotides.

REFERENCES:
patent: 4554106 (1985-11-01), DeLuca et al.
Chen et al., "Cloning of the human 1 .varies.,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and idenification of two vitamin D-responsive elements," Biochimica et Biophysica Acta, 1263:1-9 (1995).
F.H. Glorieux, "Pseudo-vitamin D deficiency rickets," Journal of Endocrinology, 154:S75-S78 (1997).
Ohyama et al., "Identification of a Vitamin D-responsive Element in the 5'-Flanking Region of the Rat 25-Hydroxyvitamin D.sub.3 24-Hydroxylase Gene," J. Biological Chemistry, 269(14):10545-10550 (Apr. 8, 1994).

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