1.alpha.-hydroxy vitamin D.sub.4 and novel intermediates and ana

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai

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552653, A61K 3159, C07C40100

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active

060253460

ABSTRACT:
Disclosed is 1.alpha.,24-dihydroxy vitamin D.sub.4 having the following structure: ##STR1## and pharmaceutical compositions containing said compound. The compound and composition are useful in the treatment of abnormal calcium metabolism. Also Disclosed is a method for the preparation of 1.alpha.,24-dihydroxy vitamin D.sub.4.

REFERENCES:
patent: 2383446 (1945-06-01), Calcott et al.
patent: 3697559 (1972-10-01), DeLuca et al.
patent: 3741996 (1973-06-01), DeLuca et al.
patent: 4195027 (1980-03-01), DeLuca et al.
patent: 4202829 (1980-05-01), DeLuca et al.
patent: 4260549 (1981-04-01), DeLuca et al.
patent: 4362710 (1982-12-01), Watanabe
patent: 4555364 (1985-11-01), DeLuca et al.
patent: 4661294 (1987-04-01), Holick et al.
patent: 4689180 (1987-08-01), DeLuca et al.
patent: 4866048 (1989-09-01), Calverley et al.
patent: 5157135 (1992-10-01), Tsuji et al.
Kirk-Othmer Encyclopedia of Chemical Technology, vol. 21, pp. 549-567 (1980).
Ishizuka, et al, Steroids, 39(1), 1982, pp. 53-62.
Ishizuka, et al, Steroids, 37(1), 1981, pp. 33-43.
DeLuca, et al, Arch. Biochem. Biophys., 124, (1968), pp. 122-128.
Morisake, et al, J.C.S. Perkin I, (1975), pp. 1421-1424.
Calverley, et al, "Vitamin D" in Antitumor Steroids, (Rt. Blickerstaff; Academic Press:San Diego, 1992) pp. 193-270.
E. Braunwald et al., Harrison's Principles of Internal Medicine: Part Eleven, "Disorders of Bone and Mineral Metabolism," Chapter 335, McGraw-Hill, New York, 1987, pp. 1860-1865.
Grab, W., Z. Physiol. Chem., 243:63-89 (1936).
McDonald, F. G., J. Biol. Chem., 114:IVX (1936).
Windaus, A. and Trautmann, G., Z. Physiol. Chem., 247:185-188 (1937).
DeLuca et al., Arch. Biochem, Biophys., 124:122-128 (1968).
Merck Index, S. Budavari (ed.), 11th ed., Merck & Co., Rahway, N.J. (1989) p. 1579, #9930.
Barton et al., JCS Perkin I, 1976, 821-826.
Paaren et al., J. Org. Chem., 1980, 45:3253.
Wientroub, S. et al., "The Dichotomy in the Effects of 1,25 dihydroxy vitamin D.sub.3 and 24,25 dihydroxy vitamin D.sub.3 on Bone Gamma-Carboxyglutamic Acid-Containing Protein in Serum and Bone in vitamin D-Deficient Rats," Calcif, Tissue Int. (1987) 40:166-172.
Sjoden, G. et al., Proc. Soc. Experimental Biol. Med., 178:432-436 (1985).
Strugnell et al., Biochem. Pharm. vol. 40:333-341 (1990).
Martin and DeLuca, Am. J. Physiol. 216:1352-1359.
Kocienski, P. J., Lythgoe, B. and Ruston, S., J.C.S. Perkins I, 1290-1293 (1979).
Tsuji, M. et al., Bull. Chem. Soc. Jpn., vol. 63, No. 8, 2233-2238 (1990).
Crump, D. R., Williams, D. H. and Pelc, B., J.C.S. Perkins Trans. I, 2731-2733 (1973).
Chemical Abstracts, vol. 113, No. 1, Jul. 2, 1990, Columbus, Ohio, US; abstract No. 6683y, Y. Tachibana, `Preparation of 1beta-hydroxyvitamin D.sub.2 and D.sub.3,` p. 6688; col. 2; *abstract* & JP-A-02 011 563 (Nisshin Flour Milling Co.).
Chemistry Letters, No. 8, Aug. 1985, Tokyo, JP, pp. 1131-1132, H. Nemeto et al., `A stereoselective synthesis of 1 alpha-hydroxy-vitamin D.sub.3 `; *the whole document*.
F. Sato et al., Biochim. Biophys. Acta, vol. 1091 (1991) pp. 188-192.

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