1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai

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Details

552653, C07C40100

Patent

active

053843142

ABSTRACT:
This invention is for 1.alpha.-fluoro-25-hydroxy-16-ene-23-yne-cholecalciferol, which can be further characterized by the formula: ##STR1## and which is useful as an agent for the treatment of sebaceous gland diseases such as acne and sebhorreic dermatitis.

REFERENCES:
patent: 5087619 (1992-02-01), Baggiolini et al.
patent: 5145846 (1992-09-01), Baggiolini et al.
patent: 5190935 (1993-03-01), Binderup et al.
patent: 5292727 (1994-03-01), Godtfredsen
Shiuey et al., J. Org. Chem. 55:243-247 (1990).
Kiegel et al., Tetrahedron Letters 32:6057-6060 (1991).

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