1-(.alpha.-Aminomethylbenzyl)isoquinoline compounds

Details 1-(.alpha.-Aminomethylbenzyl)isoquinoline compounds 1-(.alpha.-Aminomethylbenzyl)isoquinoline compounds

1974-12-20

1976-06-29

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260283R, 260288D, 260288CE, 260289D, 424248, 424258, C07D21712, C07D29512

Patent

active

039667243

ABSTRACT:
Compounds having the structure: ##SPC1##
In which R.sub.1 and R.sub.2 are alkoxy groups of one to four carbon atoms, R.sub.3 and R.sub.4 each is hydrogen or an alkoxy group of one to four carbon atoms, and R.sub.5 and R.sub.6 each is an alkyl group of one to four carbon atoms or an arylalkyl group such as benzyl or R.sub.5 taken with R.sub.6 and N are pyrrolidinyl, piperidino, or morpholino groups and the pharmaceutically acceptable salts thereof and processes for preparing these compounds. These compounds are useful as vasodilators.

REFERENCES:
patent: 3205233 (1965-09-01), Clarkson
patent: 3362956 (1968-01-01), Archer
patent: 3846432 (1974-11-01), Tanaha et al.
Tsatsas, Chem. Abstr., vol. 46, 11208i, (1952).
Wersbach et al., J. Med. Chem., vol. 11, pp. 760-764, (1968).

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