1.alpha.,3.beta.-Dihydroxy-steroid-5-enes from 1.alpha.,2.alpha.

Details 1.alpha.,3.beta.-Dihydroxy-steroid-5-enes from 1.alpha.,2.alpha. 1.alpha.,3.beta.-Dihydroxy-steroid-5-enes from 1.alpha.,2.alpha.

1978-03-30

1980-04-22

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 900

Patent

active

041995180

ABSTRACT:
Improved yields of 1.alpha.,3.beta.-dihydroxy-steroid-5-enes are obtained by the addition of the alkali metal/liquid ammonia reduction products of 1.alpha.,2.alpha.-epoxy-4,6-dien-3-one steroids to a quenching agent such as liquid ammonia/ammonium chloride mixture. Specific steroids reduced by these procedures include 1.alpha.,2.alpha.-epoxycholesta-4,6-dien-3-one and 25-hydroxy-1.alpha.,2.alpha.-epoxycholesta-4,6-dien-3-one.

REFERENCES:
patent: 3901928 (1975-08-01), Hesse et al.
patent: 3966777 (1976-06-01), Mazur et al.
Barton, et al., J.A.C.S. 95:8, 2748 (1973).

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