1-(Alkynyl)amino-1-(mercaptoalkyl)amino ethylenes

Details 1-(Alkynyl)amino-1-(mercaptoalkyl)amino ethylenes 1-(Alkynyl)amino-1-(mercaptoalkyl)amino ethylenes

1979-02-01

1980-09-09

Torrence, Dolph H.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260465E, 2604655R, 2605705P, 260583EE, 260558S, 260561A, 560 13, 560147, C07C 8724, C07C12130

Patent

active

042217377

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.1 is a straight or branched chain alkynyl group containing from 3 to 9 carbon atoms, inclusive; R.sup.2 is hydrogen, (lower)alkyl, halogen or hydroxymethyl; m is 1 or 2, and n is 2 or 3, provided that the sum of m and n is 3 or 4; X and Y each are independently hydrogen, nitro, cyano, --SO.sub.2 Ar or --COR.sup.3, provided that X and Y are not both hydrogen; R.sup.3 is (lower)alkyl, Ar, (lower)alkoxy, amino or (lower)alkylamino; and Ar is an optionally substituted phenyl group; and nontoxic pharmaceutically acceptable acid addition salts thereof, are potent anti-ulcer agents. Also disclosed are processes for their preparation and novel intermediates of the formulae ##STR2## in which R.sup.1, X, Y and n are as defined above and R.sup.5 is (lower)alkyl, phenylalkyl or phenyl containing 1 or 2 substituents independently selected from nitro, chloro and bromo.

REFERENCES:
patent: 4025529 (1977-05-01), Hollmeyer
patent: 4112234 (1978-09-01), Crenshaw et al.
patent: 4169855 (1979-10-01), Price et al.

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