1 Alkyl-4-(10:oxo or hydroxy-10,11-dihydro-5H-dibenzo[a,d]cycloh

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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424267, C07D21132

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active

039608727

ABSTRACT:
The new 1-alkyl-4-(10-oxo or -hydroxy-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-piperidine compounds are prepared from the corresponding 10-desoxy compounds having a double bond at the 10,11-position by a process involving bromination, dehydrobromination of the resulting dibromo compound, followed by enamine formation and hydrolysis to give the desired 10-oxo compound. The compounds prepared in this manner are active as antihistamines and as appetite stimulants.

REFERENCES:
patent: 3014911 (1961-12-01), Engelhardt
Neth. Patent 68,10177, Feb. 5, 1969 Derwent Basic 36,115, pp. 557-565.

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