1-alkyl-2-hydroxy-2-trifluoromethyl ethylamines

Details 1-alkyl-2-hydroxy-2-trifluoromethyl ethylamines 1-alkyl-2-hydroxy-2-trifluoromethyl ethylamines

1992-09-04

1995-05-09

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C21508

Patent

active

054141320

ABSTRACT:
The invention concerns pharmaceutically useful trifluoromethyl ketone substituted di-, tri- and tetra-peptide derivatives of the formulae Ia, Ib, Ic set out hereinafter, and salts thereof, which are inhibitors of human leukocyte elastase. Also described herein are pharmaceutical compositions containing a peptide derivative and processes and intermediates for use in the manufacture of the peptide derivatives.

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Kingsbury, C. A., et al. J. Chem. Soc. Perkin Trans. II (1982), 867.
McBee, E. T., et al. J. Amer. Chem. Soc. (1956) 78, 4053.
Cook, D. J., et al, J. Amer. Chem. Soc. (1954), 76, 83.

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