Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1988-01-11
1989-10-24
Raymond, Richard L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514654, 564374, 564428, C07C 8764, C07C 8728
Patent
active
048762849
ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.3 and the NR.sup.1 R.sup.2 group are in a cis-position to each other and wherein Y is OH, R.sup.4 COO, (R.sup.5).sub.2 NCOO or R.sup.6 O either in position 5 or position 7, whereby R.sup.4 is an alkyl group having 1-5 carbon atoms or a possibly substituted phenyl group, R.sup.5 is an alkyl group having 1-5 carbon atoms and R.sup.6 is an allyl or benzyl group, R.sup.1 is hydrogen or an alkyl group having 1-3 carbon atoms, R.sup.2 is an alkyl group having 1-6 carbon atoms, a phenylalkyl- or m-hydroxyphenylalkyl group with 2-4 carbon atoms in the alkyl part, or an alkenyl group with 3-6 carbon atoms other than 1-alkenyl, and R.sup.3 is an alkyl group having 1-3 carbon atoms, processes and intermediates for their preparation, pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.
REFERENCES:
patent: 4410519 (1983-10-01), Seiles et al.
A. T. Dren et al., Local Anesthetic Activity and Acute Toxicity of N-Substituted 1,2,3,4-Tetrahydro-1- and 2-naphthylamines, Journal of Pharmaceutical Sciences, 67, 1978.
J. D. McDermed et al., Synthesis and Pharmacology of Some 2-Aminotetralins, Journal of Medicinal Chemistry, 18, 1975.
Mulder, A. H. et al., European Journal of Pharmacology, vol. 64, (1980), pp. 349-355.
Arvidsson Folke L. E.
Carlsson Per A. E.
Hacksell Uli A.
Hjorth John S. M.
Johansson Anette M.
Konstas Kristina L.
Per Arvid Emil Carlsson
Raymond Richard L.
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