1-alkyl-2-aminotetralin derivatives

Details 1-alkyl-2-aminotetralin derivatives 1-alkyl-2-aminotetralin derivatives

1989-09-29

1994-02-15

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514513, 514532, 514533, 514534, 514546, 514654, 514657, 560 66, 560 72, 560 73, 560221, 560157, 560163, 564374, 564428, A01K 3127, C07C27108

Patent

active

052867471

ABSTRACT:
Compounds of the formula ##STR1## wherein R.sup.3 and the NR.sup.1 R.sup.2 group are in a cis-position to each other and wherein Y is OH, R.sup.4 COO, (R.sup.5).sub.2 NCOO or R.sup.6 O either in position 5 or position 7, whereby R.sup.4 is an alkyl group having 1-5 carbon atoms or a possibly substituted phenyl group, R.sup.5 is an alkyl group having 1-5 carbon atoms and R.sup.6 is an allyl or benzyl group, R.sup.1 is hydrogen or an alkyl group having 1-3 carbon atoms, R.sup.2 is an alkyl group having 1-6 carbon atoms, a phenylalkyl- or m-hydroxyphenylalkyl group with 2-4 carbon atoms in the alkyl part, or an alkenyl group with 3-6 carbon atoms other than 1-alkenyl, and R.sup.3 is an alkyl group having 1-3 carbon atoms, processes and intermediates for their preparation, pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.

REFERENCES:
patent: 4410519 (1983-10-01), Seiler et al.
Mulder et al., European Journal of Pharmacology vol. 64, No. 4, 27, Jun. 1980.
McDermed et al., "Journal of Medical Chemistry, Synthesis and Pharmacology of Some 2-Aminotetralins . . . " 1975, vol. 18, No. 4.

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