1-alkyl-2-acyl-1,2-disulfonylhydrazines

Details 1-alkyl-2-acyl-1,2-disulfonylhydrazines 1-alkyl-2-acyl-1,2-disulfonylhydrazines

1991-11-08

1993-10-26

Robinson, Allen J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C07C31102, C07C31114, C07C31115, A61K 3118

Patent

active

052568202

ABSTRACT:
Novel antineoplastic 1-alkyl-2-acyl-1,2-disulfonylhydrazine having the following formula and methods of therapy using those antineoplastic compounds: ##STR1## where R.sub.1 and R.sub.2 are (independently) alkyl, cycloalkyl, aryl, aralkyl or heteroaryl. X is an acyl group, and Z is an alkyl or a haloalkyl group.

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Shyam et al., "Synthesis and Evaluation of 1,2,2-Tris(sulfonyl)hydrazines as Antineoplastic and trypanocidal Agents", J. Med. Chem., 30:2157-2161 (1987).
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