1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazines having ant

Details 1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazines having ant 1-alkyl-1-sulfonyl-2-alkoxycarbonylsulfenylhydrazines having ant

1987-06-04

1990-10-09

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514374, 514407, 514408, 514445, 548215, 548373, 548378, 549 65, 546178, A61K 3177, A61K 3138, C07D26346, C07D21536

Patent

active

049621149

ABSTRACT:
Compounds of the formula: ##STR1## wherein R.sub.1 is a lower alkyl of 1-6 carbon atoms, benzyl, phenyl or phenyl substituted by halogen, alkoxy of 1 to 4 carbon atoms, alkyl of 1 to 4 carbon atoms, amino, or carbonyl substitutents, or --RN(R').sub.2 wherein R and R' are each independently alkyl of 1 to 4 carbon atoms; R.sub.2 is an aromatic substituent, and each A is an aromatic substitution indpendently selected from the group consisting of hydrogen, alkyl of 1-4 carbon atoms, alkoxy of 1-4 carbon atoms, halogen, --NO.sub.2, --NH.sub.2,--COOH, and --NHCOCH.sub.3. The compounds have been found to be alkylating agents having antineoplastic activity for use in inhibiting the growth of tumors.

REFERENCES:
patent: 3975530 (1976-08-01), Durant et al.
patent: 4375472 (1983-01-01), Durant et al.
patent: 4849563 (1989-07-01), Sartorelli et al.
patent: 4892887 (1990-01-01), Sartorelli et al.
"Synthesis and Evaluation of 1-(Arylsulfonyl)-2 [(Methoxycarbonyl)sulfenyl]-1-methylhydrazines . . . ", Hrubiec et al., Journal of Medicinal Chemistry, vol. 29, No. 9, Sep. 1986, pp. 1777-1779.

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