Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-06-27
2006-06-27
Owens, Amelia A. (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C544S281000
Reexamination Certificate
active
07067521
ABSTRACT:
The invention relates to an imidazo[1,2-a]pyrimidone derivative represented by formula (1) or a salt thereof, wherein: X represents a bond, an ethenylene group, and ethenylene group, a methylene group optionally substituted by one or two groups selected from a C1-6alkyl group, a hydroxy group and a C1-4alkoxy group; a carbonyl group, an oxygen atom, a sulfur atom, a sulfonyl group, a sulfoxide group or a nitrogen atom being optionally substituted by a C1-6alkyl group; R1 represents a 2,3 or 4-pyridyl group optionally substituted by a C1-4alkyl group, C1-4alkoxy group or a halogen atom; R2 represents a C1-6alkyl group, a C1-2perhalogenated alkyl group, a C1-3halogenated alkyl group, a benzyl group, a phenyl ring, a naphthyl ring, 5,6,7,8-tetrahydronaphthyl ring, a pyridyl ring, an indole ring, a pyrrole ring, a thiophene ring, a furan ring or an imidazole ring, the benzyl group and the rings being optionally substituted by 1 to 4 substituents selected from a C1-6alkyl group, a phenyl ring, a halogen atom, a C1-2perhalogenated alkyl group, a C1-3halogenated alkyl group, a hydroxyl group, a C1-4alkoxy group, a nitro, a cyano, an amino, a C1-6monoalkylamino group or a C2-10dialkylamino group; and n represents 0 to 3. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer disease.
REFERENCES:
patent: 6096753 (2000-08-01), Spohr et al.
patent: WO 00/18758 (2000-04-01), None
Alonso M and Martinez A, Current Medicinal Chemistry, 2004, 11:755-763.
Witherington et al. Bioorganic & Medicinal Chemistry Letters. 2003, 13:1577-1580.
Lochead Alistair
Marguerie Séverine
Saady Mourad
Yaiche Philippe
Gupta Balaram
Owens Amelia A.
sanofi-aventis
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