Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-04-21
1996-11-12
Chang, Ceila
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
546175, 546334, 546314, 548247, 548502, 549 76, 549 77, 568426, C07C 4711, C07C 47115
Patent
active
055741649
ABSTRACT:
Novel 1-alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols, intermediates and processes for the preparation thereof, and methods of reducing inflammation and cell proliferation, and relieving memory dysfunction, and inhibiting bacterial and fungal growth are disclosed.
REFERENCES:
patent: 5321165 (1994-06-01), DiBerardino et al.
A. Hajos, Acta Chimica Academiae Scientarum Hungaricae, 84, 471 (1975) published in Hungary & entitled "Synthesis of threo-and erythro-.beta.-o-tolylserine and their derivatives."
S. Van Der Meer, et al., Recueil, 72, 236 (1953) published in the Netherlands and entitled "Chloramphenicol Analogues I".
J. Morris & D. G. Wishka, Tetrahedron Letters, 29, 143 (1988) published in Great Britain and entitled "Synthesis of Novel Antagonists of Leukotriene B.sub.4 ".
K. Sonogashira, et al. Tetrahedron Letters, 50, 4467 (1975) published in Great Britin and entitled "A Convenient Synthesis of Acetylenes: Catalytic Substitutions of Acetylenic Hydrogen with Bromoalkenes, Iodoarnes, and Bromopyridines".
J. E. Parks, et al., Inorganic Chemistry, 10, 2472 (1971) published in the United States of America and entitled "Three-Dimensional Macrocyclic Encapsulation reactions, II. Synthesis and Properties of Nonoctahedral Clathro Chelates Derived from Tris(2--aldoximo--6--pyridyl)phosphine and Boron Trifluoride or Tetrafluoroborate".
E. L. Smith and J. J. Tegeler, Annual Reports in Medicinal Chemistry, 24, 13 (1989) published in the United States of America and entitled "Chapter 19. Advances in Dermatology".
A. K. Gupta, et al., The Journal of Investigative Dermatology, 91, 486 (1988) published in the United States of America and entitled "Sphingosine Inhibits Phorbol Ester-Induced Inflammation, Ornithine Decarboxylase Activity, and Activation of Protein Kinase C in Mouse Skin".
Ng. Ph. Buu Hoi, et al., Chemical Abstracts, 45, 9005i (1951) published in the United States of America and entitled "Three new analogs of chloramphenicol ".
H. M. Crooks, Jr., et al., Chemical Abstracts, 46, 9602c (1952) published in the United States of America and entitled "Diarylphenylpropaneaminodiols".
Parke, Davis & Co., Chemical Abstracts, 48, 8823g (1954) published in the United States of America and entitled "Organic amino diols".
Parke, Davis & Co., Chemical Abstracts, 47, 3347d (1952) published in the United States of America and entitled "Amino diols".
H. M. Crooks, Jr., et al., Chemical Abstracts, 45, 633a (1951) published in the United States of America and entitled "(Nitrophenyl)acylaminoalkane diols".
L. M. Long and N. D. Jenesel, Chemical Abstracts, 45, 9564b (1951) published in the United States of America and entitled "Furan compounds".
E. C. Hermann, Chemical Abstracts, 50, 5760c (1956) published in the United States of America and entitled "Thienyl amido--1, 3--propanediols".
Duke Univ., Derwent 88-091694113 published May 25, 1988 in Great Britain and entitled "Inhibition of protein kinase C with amphipathic long-chain base-esp. with sphingosine, for treating asthma, inflammation, psoriasis or tumour metastasis."
M. Miyoshi, et al., Chemical Abstracts, 92, 198778a (1980) published in the United States of America and entitled ".beta.-Hydroxyamino acids".
F. A. Arena, et al., Chemical Abstracts, 89, 59826q (1978) published in the United States of America and entitled "Structure-activity relations in acetylcholinesterase reactivators inhibited by phosphoric esters. XII. Hydroxyiminomethylalkylpiridine methiodides".
S. Nimkar, et al., Tetrahedron Letters, 29, 3037 (1988) published in Great Britain and entitled "A Stereoselective Synthesis of Sphingosine, A Protein Kinase C Inhibitor".
Y. Gao, et al., Journal of the American Chemical Society, 109, 5765 (1987) published in the United States of America and entitled "Catalytic Asymmetric Epoxidation and Kinetic Resolution: Modified Procedures Including in Situ Derivatization".
S. Knapp, et al., Journal of Organic Chemistry, 55, 5700(1990) published in the United States of America & entitled "Amino Alcohol and Amino Sugar Synthesis by Benzoylcarbamate Cyclization".
P. Garner & J. M. Park, Journal of Organic Chemistry, 52, 2361(1987) published in the United States of America & entitled "The Synthesis and Configurational Stability of Differentially Protected .beta.--Hydroxy--.alpha.--amino Aldehydes".
D. P. Schumacher, et al, Journal of Organic Chemistry, 55, 5291 (1990) published in the United States of America & entitled "An Efficient Synthesis of Florfenicol".
D. A. Evans & A. E. Weber, Journal of the Am. Chem. Soc., 109, 7151 (1987) published in the United States of America & entitled "Synthesis of the Cyclic Hexapeptide Echinocandin D. New Approaches to the Asymmetric Synthesis of .beta.-Hydroxy .alpha.-Amino Acids".
Y. Nishizuka,Nature,308, 693 (1984) published in Great Britain & entitled "The role of protein kinase C in cell surface signal transduction and tumour promotion".
L. Hegemann, et al., Archives of Dermatological Research,281,561 (1990) published in Germany & entitled "Inhibitors of proteinkinase C express antiproliferative properties in keratinocytes in vitro".
L. Hegemann and G. Mahrle in "Pharmacology of the Skin", H. Muktar, Ed; CRC Press, Ann Arbor, Michigan, pp. 357 to 368, 1992.
J. J. Tegeler, et al., Chemical Abstracts, published in the United States of America and entitled "Preparation of Heteroarylaminoalkanols".
Zhang et al. "A convenient synthesis of fluoroaromatic acetylene derivatives"CA 113:114702n (1990).
Villemin et al. "Pd-homogeneous and supported catalysis: synthesis of functional acetylenics and cyclisation to heterocyclces"Heterocycles v. 209, 1255-1261 (1989).
Freed Brian S.
Hamer Russell R. L.
Merriman Gregory H.
Rauckman Barbara S.
Tegeler John J.
Chang Ceila
Hoescht Roussel Pharmaceuticals Inc.
Wittekind Raymond R.
LandOfFree
1-alkyl-,1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-alkyl-,1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-alkyl-,1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-563821