Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2007-12-04
2007-12-04
Anderson, Rebecca (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S517000, C548S518000
Reexamination Certificate
active
10531884
ABSTRACT:
Anti-viral agents of Formula (I)wherein:A represents hydroxy; D represents aryl or heteroaryl; E represents hydrogen, C1-6alkyl, aryl, heteroaryl or heterocyclyl; G represents hydrogen or optionally substituted C1-6alkyl; J represents C1-6alkyl, heterocyclylalkyl, arylalkyl or heteroarylalkyl; and salts, solvates and esters thereof; provided that when A is esterified to form —OR where R is selected from straight or branched chain alkyl, aralkyl, aryloxyalkyl, or aryl, then R is other than tert-butyl; processes for their preparation, pharmaceutical compositions comprising them, and methods of using them in HCV treatment are provided.
REFERENCES:
patent: 96/33170 (1996-10-01), None
patent: 9929705 (1999-06-01), None
patent: 99/37204 (1999-07-01), None
patent: WO 99/54299 (1999-10-01), None
patent: WO 00/09543 (2000-02-01), None
patent: WO 01/85720 (2001-11-01), None
patent: 02/44168 (2002-06-01), None
patent: 03037893 (2003-05-01), None
patent: 03037896 (2003-05-01), None
patent: 2004037618 (2004-06-01), None
Ojima et al, 1991, Journal of Organometallic Chemistry, vol. 417(1-2), pp. 253-276.
Chronic Hepatitis C: Current Disease Management, retrieved from Internet on Apr. 9, 2007, <http://digestive.niddk.nih.gov/ddiseases/pubs/chronichepc/index.htm>.
Liang et al, Feb. 15, 2000, Annals of Internal Medicine, vol. 132(4), pp. 296-305.
Syed, R.H., et al. “2,5-Disubstituted Pyrrolidines: Versatile Regioselective and Diastereoselective Synthesis by Enamine Reduction and Subsequent Alkylation.” Organic & Biomolecular Chemistry, vol. 1, No. 11, May 28, 2003, pp. 1838-1841.
Sato et al.; Heterocycles: 1994: 37/1; 245-248.
P. De Caprariis G De Martino, E. Abignente, P Avara, L. Mayo: Pyrrolo[1,4]benzodiazepines. IV Synthesis of E. and Z-5.11-Dioxo-11a-ethoxycarbonyl-2-ethylidine-1,2,3,10.11, 11a-hexahydro-5Hyrrolo[2.1-o][1,4] benzodiezepine: J. Heterocyclic Chem.: Jan. 89; 26: 1023-1027.
Gardiner, James et al.; Synthesis and solid state conformation of phenylalanine mimetics constrained in a proline-like conformation; Organic & Biomolecular Chemistry; Jul. 27, 2004; 2(16); 2365-2370.
Ikeda M., et al.; Synthesis of tricyclic nitrogen-containing heterocycles by palladium-catalyzed cyclization of 2-alkenyl-n-(o-iodobenzoyl)- and 2-alkenyl-n-(o-iodophenylacetyl)-pyrroidines: Heterocycles: 1998; 42; pp. 155-158.
Confalone P.N., et al.; Design and synthesis of potential DNA cross-linking reagents based on the anthramycin class of minors groove binding compounds; J. Org. Chem.; 1988; 63: pp. 482-487.
Alig I., et al., Low molecular weight, non-peptide fibrinogen receptor antagonists: J. Med. Chem.; 1992; 35; pp. 4393-4407.
Padwa A., et al.; Transmutations of 1,3-dipoles: The conversion of a-diazo ketones into azomethine ylides via carbonyl ylides; J. Am. Chem. Soc.; 1992; 114; pp. 593-601.
Culbertson T.P., et al.; Quinoione antibacterial agents substituted at the 7-position with aplinoamines. Synthesis and structure-activity relationships; J. Med. Chem.; 1990; 33, pp. 2270-2275.
Crooks, P.A., et al.; Synthesis of 5-hydroxy- and 5,6-dihydroxy-derivatives of spiro[indano-2-2'-pyrroiidine]. rigid analogues of tyramine and dopamine respectivity; Journal of the Chemical Society, Perkins Transactions 1; 1979; 11; pp. 2719-2726.
De Martino G., et al.; La Reazione Tra 2-Nitrobenzolaminomalonato Ed Aideide Acritica Per LA Sintesi Di Composti A Strutlura Parrolo[2,1-c][1,4]Benzodiazepinica (english summary only); Farmaco Ed Sc.; 1976; 31(11); pp. 786-790.
Ikeda et al.; Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry; 1997: 22; 3339-3344.
Sato et al., Journal of the Chemical Society, Perkin Transactions 1, 1995; 14; 1801-1809.
Haigh David
Hartley Charles David
Howes Peter David
Jackson Deborah Lynette
Shah Pritom
Anderson Rebecca
Cheng Karen
Glaxo Group Limited
Prus Karen L.
LandOfFree
1-acyl-pyrrolidine derivatives for the treatment of viral... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1-acyl-pyrrolidine derivatives for the treatment of viral..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-acyl-pyrrolidine derivatives for the treatment of viral... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3875023