1-Acyl-8-(3-amino-2-hydroxypropoxy)-1,2,3,4-tetrahydroquinolines

Details 1-Acyl-8-(3-amino-2-hydroxypropoxy)-1,2,3,4-tetrahydroquinolines 1-Acyl-8-(3-amino-2-hydroxypropoxy)-1,2,3,4-tetrahydroquinolines

1980-08-15

1982-06-15

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424851, 42424854, 424250, 424258, 544128, 544 586, 544363, 546165, A61K 3154, A61K 3147, C07D21526, C07D41712

Patent

active

043351239

ABSTRACT:
A 1-acyl-8-[2,3-epoxypropoxy]- and/or 1-acyl-8-[3-halo-2-hydroxypropoxy]-1,2,3,4-tetrahydroquinoline are reacted with primary and secondary amines to obtain corresponding physiologically-active 1-acyl-8-[3-amino-2-hydroxypropoxy]-1,2,3,4-tetrahydroquinolines and pharmacologically-acceptable acid-addition salts thereof. These compounds are useful as such or in conventional medicament compositions for treating those afflicted with heart ailments and/or hypertension.

REFERENCES:
patent: 3056792 (1962-10-01), Geschickter et al.
patent: 3444173 (1969-05-01), Goldman
Crowther, A. F., et al., ".beta.-Adrenergic Blocking Agents, 12, Heterocyclic Compounds Related to Propanolol", Journal of Medicinal Chemistry, vol. 15, No. 3, 260-266, 1972.

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