1-Acyl-3-(amino-lower-alkyl)indoles

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546201, 546273, 424246, 4242484, 4242485, 42424851, 42424852, 42424854, 424250, 424260, 424267, 424274, 544 62, 544143, 544144, 544373, C07D40106, C07D20914

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041608623

ABSTRACT:
1-Acyl-3-(amino-lower-alkyl)indoles, useful as anti-inflammatory agents, are prepared either by acylation of a 3-(amino-lower-alkyl)indole; by Fisher indole synthesis from an N'-acylphenylhydrazine and an amino-lower-alkanone; by alkylation of an amine with a 1-acyl-3-(halo-lower-alkyl)indole; or by reductive alkylation of a 1-acyl-3-indole-lower-alkylcarboxaldehyde.

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