Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-10-28
1990-11-06
Shah, Mukund J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514256, 514311, 514313, 514314, 544224, 544238, 544333, 544335, 546159, 546168, 546172, A61K 31505, A61K 3147, A61K 31495
Patent
active
049686801
ABSTRACT:
The present invention relates to novel 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime-O-sulfonic acid compound, processes for producing said compounds, intermediate compounds to produce said compounds and compositions containing said compounds with potent diuretic activity that can be used for treating and/or preventing hypertension, oedema and/or for removing ascites.
The present invention is based on the selection of 1-acyl-7-halo-2,3-dihydro-4(1H)-quinolinone-4-oxime-O-sulfonic acid compounds, namely heterocyclic-or fused heterocyclic- carbonyl derivatives at 1 position.
The compounds of the present invention containing these substituents have potent hypotensive, antioedematous and diuretic effect as well as an activity to remove ascites and are extremely useful for the treatment of diseases and disorders mentioned above.
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Haga Akinori
Kato Kazuo
Mochida Ei
Tokunaga Hiroki
Uemura Akio
Hodogaya Chemical Co. Ltd.
Mochida Pharmaceutical Co. Ltd.
Shah Mukund J.
Ward E. C.
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