1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives

Details 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives

1987-04-27

1989-06-13

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546159, 546 23, 546153, 546156, 544337, 544405, 544406, 514253, C07D21542, C07D40106, C07F 960, A61K 3147

Patent

active

048393681

ABSTRACT:
The present invention relates to novel 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, processes for producing said derivatives, intermediate compounds to produce said derivatives, processes to produce said intermediate compounds, and compositions containing said derivatives with potent diuretic activity that can be used for treating and/or preventing hypertension, oedema and/or for removing ascites.
The present invention is based on the selection of 1-acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivatives, namely O-sulfate, O-mesylate, O-methylphosphate and O-carboxymethyl ether, especially O-sulfate of 4-oxime.
The compounds of the present invention containing these substituents have potent hypotensive, anti-oedematous and diuretic effect as well as an activity to remove ascites and are extremely useful for the treatment of diseases and disorders mentioned above.

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