1,9-Dihydroxyoctahydrobenzo[c]quinolines and 1-hydroxyhexahydrob

Details 1,9-Dihydroxyoctahydrobenzo[c]quinolines and 1-hydroxyhexahydrob 1,9-Dihydroxyoctahydrobenzo[c]quinolines and 1-hydroxyhexahydrob

1979-06-26

1980-10-14

Friedman, Stanley J.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424850, 42424851, 42424854, 42424857, A61K 2700, A61K 3147

Patent

active

042281695

ABSTRACT:
1,9-Dihydroxyoctahydro[c]quinolines (I) and 1-hydroxyhexahydrobenzo[c]quinoline-9(8H)-ones (II), useful as antiemetic agents and derivatives thereof having the formulae ##STR1## wherein R is hydroxy or alkanoyloxy having from one to five carbon atoms; R.sub.1 is hydrogen, benzyl, benzoyl, alkanoyl having from one to five carbon atoms or --CO--(CH.sub.2).sub.p --NR.sub.2 R.sub.3 wherein p is 0 or an integer from 1 to 4;

REFERENCES:
patent: 4087545 (1978-05-01), Archer
Sallen et al., N. Eng. J. Med. 293, 795 (1975).
Borison et al., N. Eng. J. Med. 298, 1480 (1978).

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