Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-11-01
2005-11-01
Desai, Rita (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C546S122000, C544S336000, C544S106000
Reexamination Certificate
active
06960598
ABSTRACT:
A class of [1,8] naphthyridine analogues which are substituted in the 4-position by a substituted phenyl ring. These compounds are ligands for GABAAreceptors and useful in the therapy of deleterious mental states such as anxiety.
REFERENCES:
patent: WO 01 38326 (2001-05-01), None
Settimo Da A, et al: “Synthesis and Benzodiazepine Receptor Activity of Some 4, 5-Dihydro-1H-Pyrazolo 4,3-C1,8 Naphthyridine Derivatives”, Drug Design and Discovery, 1994, vol. 11, pp. 307-328.
Cinone N, et al: “Development of a Unique 3D Interaction Model of Endogenous and Synthetic Peripheral Benzodiazepine Receptor Ligands”, Journal of Computer-Aided Molecular Design, 2000, vol. 14, No. 8, pp. 753-768.
Teuber L, et al: “Ligands for the Benzodiazepine Binding Site—A Survey”, Current Pharmaceutical Design, 1999, vol. 5, pp. 317-343.
Martin I L, et al: “Benzodiazepine Recognition Site Ligands and GABAA Receptors”, Expert Opinion on Therapeutic Patents, 1999, vol. 9, No. 10, pp. 1347-1358.
Carling William Robert
Mitchinson Andrew
Russell Michael Geoffrey
Street Leslie Joseph
Desai Rita
Merck Sharp & Dohme Ltd.
Thies J. Eric
Winokur Melvin
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