Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-09-19
2006-09-19
Shameem, Golam M. M. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C544S127000, C544S362000, C546S183000, C514S253040, C514S299000
Reexamination Certificate
active
07109196
ABSTRACT:
The invention relates generally to naphthyridine derivatives of the formulawherein one of U, X, Y and Z is nitrogen and the others are C—R, where R is hydrogen or a substituent. More specifically, the invention relates to 1,8-naphthyridine derivatives and pharmaceutical compositions containing such derivatives. Methods of the invention comprise administration of a naphthyridine derivative of the invention for the treatment of diabetes and related disorders.
REFERENCES:
patent: 4284629 (1981-08-01), Grohe et al.
patent: 4616019 (1986-10-01), Chu
patent: 4767762 (1988-08-01), Chu
patent: 4810708 (1989-03-01), Ganguly et al.
patent: 4840954 (1989-06-01), Petersen et al.
patent: 4881969 (1989-11-01), Saupe et al.
patent: 4988705 (1991-01-01), Ganguly et al.
patent: 4999045 (1991-03-01), Saupe et al.
patent: 5116840 (1992-05-01), Ganguly et al.
patent: 5126352 (1992-06-01), Ganguly et al.
patent: 5245037 (1993-09-01), Kuramoto et al.
patent: 5439916 (1995-08-01), Ganguly et al.
patent: 5658924 (1997-08-01), Matsuura et al.
patent: 5686251 (1997-11-01), Horiuchi et al.
patent: 5817669 (1998-10-01), Tomita et al.
patent: 5817670 (1998-10-01), Takayama et al.
patent: 5891878 (1999-04-01), Beasley et al.
patent: 5994367 (1999-11-01), Lee et al.
patent: 6071930 (2000-06-01), Lee et al.
patent: 6229016 (2001-05-01), Lee et al.
patent: 6274592 (2001-08-01), Sawa
patent: 6297248 (2001-10-01), Shimamoto et al.
patent: 6306856 (2001-10-01), Sawa
patent: 6306865 (2001-10-01), Pendergast et al.
patent: 6307059 (2001-10-01), Chang et al.
patent: 6331548 (2001-12-01), Shimamoto et al.
patent: 6331555 (2001-12-01), Hirth et al.
patent: 9885096 (2001-12-01), Sawa
patent: 6423721 (2002-07-01), Harris et al.
patent: 6677352 (2004-01-01), Wang et al.
patent: 6900205 (2005-05-01), Wang et al.
patent: 0227088 (1987-07-01), None
patent: 0612731 (1994-08-01), None
patent: 2124871 (1990-05-01), None
patent: H 9221424 (1997-08-01), None
patent: 9207468 (1992-05-01), None
patent: 9915526 (1999-04-01), None
patent: 9964051 (1999-12-01), None
patent: 0008026 (2000-02-01), None
patent: 0071524 (2000-11-01), None
patent: 0181340 (2001-11-01), None
U.S. Appl. No. 09/907,741, filed Jan. 17, 2002, Shimamoto et al.
Yamashita, Y., Ashizawa, T., Morimoto, M., Hosomi, J., Nakano, H., “Antitumor Quinolones with Mammalian Topoisomerase II Mediated DNA Cleavage Activity”, Cancer Research, 52: 2818-2822 (May 1992).
Wentland, M., Perni, R., Dorff, P., Brundage, R., Castaldi, M., Bailey, T., Carabateas, P., Bacon, E., Young, D., Woods, M., Rosi, D., Drozd, M., Kullnig, R., Dutko, F., “3-Quinolinecarboxamides. A Series of Novel Orally-Active Antiherpetic Agents”, J. Med. Chem., 36: 1580-1596 (1993).
Sochneva, E., Solov'eva, N., Granik, V., “Acetals of Lactams and Acid Amides. XXIX. * Synthesis of 1,8-Naphthyridine and Pyrido[2,3-d] Pyrimidine Derivatives”, S. Ordzhonikidz All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow 119021. Translated from Khimiya Geterotsiklicheskikh Soedinenil, No. 12, pp. 1671-1676, Dec. 1978.
Schwan, T., Lougheed, G., “An Octahydropyrido [3,4-g] Isoquinoline, A New Ring System”, Notes, 441 (Apr. 1975).
Matsuura, A., Ashizawa, N., Asakura, R., Kumonaka, T., Aotsuka, T., Hase, T., Shimizu, C., Kurihara, T., Kobayashi, F., “Substituted 1,8-Naphthyridin-2(iH)-ones as Selective Phosphodiesterase IV Inhibitors”, Biol. Pharm. Bull., 17(4): 498-503 (1994).
Kondo, H., Taguchi, M., Inoue, Y., Sakamoto, F., Tsukamoto, G., “Synthesis and Antibacterial Activity of Thiazolo-, Oxazolo-, and Imidazolo [3,2-a][1,8] Naphthyridinecarboxylic Acids”, J. Med. Chem., 33: 2012-2015 (1990).
Kim, D., “The Chemistry of 5H-Benzoxazolo [3,2-a] Quinolin-5-ones. 5H-Benzoxazolo [3,2-a] Quinolin-5-ones as Synthons for the Preparation of Novel Quinoline Derivatives”, J. Hetercyclic Chem., 18: 1393-1397 (1981).
Hermecz, I., Meszaros, Z., Vasvari-Debreczy, L., Horvath, A., Horvath, G., Pongor-Csakvari, M., “Nitrogen Bridgehead Compounds. Part 4. 1→ 3N→ C-Acyl Migration. Part 2.”, J.C.S. Perkins I, 789-795, (1977).
Guss, L., Khabarova, L., Ershov, L., Dvoryantseva, G., Proshina, N., Granik, V., “Lactam and Acid Amide Acetals 57.* Synthesis, Protonation, and Acid-Base Properties of Condensed Derivatives of 4-Oxo-1,4-Dihydro-1,8-Naphthyridine”, S. Ordzhonikidz All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow 119021. Translated from Khimiya Geterotsiklicheskikh Soedinenil, No. 5, pp. 643-951, May 1990.
Granik, V., Persianova, I., Sochneva, E., Anisimova, O., Sheinker, Y., “Acetals of Lactams and Acid Amides. 30.* Ionization Constants of Derivatives of 1,8-Naphthyridine”, S. Ordzhonikidz All-Union Scientific-Research Pharmaceutical-Chemistry Institute, Moscow 119021. Translated from Khimiya Geterotsiklicheskikh Soedinenil, No. 9, pp. 1255-1257, Sep. 1979.
Fulop, F., Hernecz, I., Meszaros, Z., “Nitrogen Bridgehead Compounds. IX. Synthesis and Reactions of 2,3-Disubstituted Pyrido[1,2-a] Pyrimidin-4-ones”, J. Hetercyclic Chem., 16: 457-460 (1979).
Friary, R., Schwerdt, J., Seidl, V., Villani, F., “A Synthesis of Imidazo- and Pryimido[1,2-g][1,6] Naphthyridinones”, J. Hetercyclic Chem., 27: 189-193 (1990).
Ferrarini, P., Mori, C., Livi, O., Biagi, G., Marini, A., “Synthesis of Some Substituted Pyrido [1.2-a] Pyrimidin-4-ones and 1,8-Naphthyridines”, J. Heterocyclic Chem., 20: 1953-1057 (1983).
Dominquez, J., Basante, W., Charris, J., Riggione, F., “Synthesis and Activity of Some Quinolone Derivatives Against Plasmodium Falciparum In Vitro”, II Farmaco, 51(6): 407-412 (1996).
Chung, S., Kim, D., “Synthesis of 3-Fluoro-2-Subbstituted Amino-5, 12-Dihydro-5-Oxobenzoxazolo [3,2-a] Quinoline-6-Carboxylic Acids Employing the Tandem Double Ring Closure Reaction of N-Acetyl-N-(2-Hydroxyphenyl) Anthranilic Acid as the Key Step”, Tetrahedron, 51: 12,549-12,562 (1995).
Chemical Abstract XP-002222061, Hermecz, I., Horvath, A., “Nitrogen Bridgehead Compounds. Part 83 [1]. Synthesis and Ring Transformation of 6-Methyl-4-Oxo-4H-Pyrido[1,2-a] Pyrimidine-3-Acrylates”, J. Hetercyclic Chem., 29: 559-564 (1992).
Friary, R., Seidl, V., Schwerdt, J., Cohen, M., Hou, D., Nafissi, M., “Intramolecular Transaminations of Enaminones: A Synthesis of Fused, Polycyclic, N-Aryl Pyridones”, Tetrahedron, 49: 7169-7178 (1993).
Chemical Abstract XP-002222063, Osborne, A., Goolamali, Z., “1H and—C NMR Spectral Studies of Some 4H-3, 1-Benzoxazin-4-ones and Their 2-Acrylaminobenzoic Acid Precursors”, Spectrochimica Acta Part A, 56: 1079-1100 (2000).
Chemical Abstract XP-001119052, Ming, Y., Horlemann, N., Warnhoff, H., “Heterocondensed Pyridines by Cycloaddition-Extrusion Sequence of Bi- and Tricyclic 1,3-Oxazinones with N, N-Diethyl-1-Propynylamine”, Chem. Ber., 120: 1427-1431 (1987).
Chemical Abstract XP-002222062, Chu, D., Claiborne, A., “Practical Synthesis of Iminochlorothioformates: Application of Iminochlorothioformates in the Synthesis of Novel 2,3,4,9-Tetrahydroisothiazolo [5,4-b][1,8] Naphthyridine-3,4-Diones and 2,3,4,9-Tetrahydroisothiazolo[5,4-b]Quinoline-3,4-Dione Derivatives”, J. Hetercyclic Chem., 27: 1191-1195 (1990).
Patent Abstracts of Japan, Pub. #03058992, Pub. Date: Mar. 14, 1991, Yoshikazu, F., “New Isothiazolo-Naphthylidine, Isothiazoloquinoline Derivatives and Salt Thereof”.
Patent Abstracts of Japan, Pub. #03223289, Pub. Date Feb. 10, 1991, Katsuhisa, N., “Thienoquinoline Derivative, Thienonaphthyridine Derivative and Salt Thereof”.
Abstract, 1986:626520, 2002 American Chemical Society, Matsumoto, J., Koshi, M., Uno, J., Natkamura, S., “Novel Naphthyridine Derivatives and Their Esters and Salts”, JP 05061276.
Abstract, 1996:543886, 2002 American Chemical Society, Fujiwara, S., Okamura, J., Takai, H., Nonaka, H., Moryama, “Preparation of Quinazoline Derivativ
Bullock William H.
Gunn David E.
Li Tindy
Liang Sidney X.
Liu Donglei
Bayer Pharmaceuticals Corporation
Pellegrino Susan M.
Shameem Golam M. M.
LandOfFree
1,8 Naphthyridine derivatives and their use to treat... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,8 Naphthyridine derivatives and their use to treat..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,8 Naphthyridine derivatives and their use to treat... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3582328