1,8-Naphthyridine compounds and process for preparing the same

Details 1,8-Naphthyridine compounds and process for preparing the same 1,8-Naphthyridine compounds and process for preparing the same

1978-12-13

1980-01-08

Randolph, John D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424256, 546123, C07F 502, C07D48704

Patent

active

041828801

ABSTRACT:
1,8-Naphthyridine compounds and a process for preparing chelated 1,8-naphthyridine derivatives and 1,8-naphthyridine derivatives which are pharmacautically useful compounds. Chelated 1,8-naphthyridine derivatives of the general formula [I]: ##STR1## wherein X and Y are independently a lower alkyl group, are prepared by subjecting a compound of the general formula [II]: ##STR2## wherein X and Y are as defined above and R is a lower alkyl group, to ring-closing condensation in the presence of boron trifluoride and/or a boron trifluoride complex at an elevated temperature, and 1,8-naphthyridine derivatives of the general formula [III]: ##STR3## wherein X and Y are as defined above, are prepared by treating the chelated 1,8-naphthyridine derivatives with water and/or an alcohol. The desired products can be readily obtained in high yields. The chelated compounds are novel compounds.

REFERENCES:
patent: 3296274 (1967-01-01), Stafiej et al.
patent: 3813406 (1974-05-01), Wada et al.
patent: 3849421 (1974-11-01), Nakagome et al.
patent: 3963736 (1976-06-01), Nakagome et al.

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