1,8-Naphthyridine compounds

Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal

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2602948C, 260296N, 424263, C07D21344

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active

040311031

ABSTRACT:
There is described 2-amino-5,7-disubstituted-naphthyridine and 5,7-disubstituted-naphthyridin-2(1H)-one derivatives with bronchodilating and hypotensive properties prepared by the reaction of 2,6-diaminopyridine with an appropriate .beta.-diketone providing the 2-amino products. The 2-oxo analogs are prepared from the 2-amino products by treatment with nitrous acid.

REFERENCES:
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patent: 3843663 (1974-10-01), Williams et al.
patent: 3962262 (1976-06-01), Williams et al.
Ochiai et al., Ber. Deut. Chem., vol. 74, pp. 1115 to 1126 (1941).
Elderfield, Heterocyclic Compounds, vol. 7, front page and pp. 206-207 and 232, John Wiley and Sons, Inc. (1961).

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