1,6 Naphthyridines useful as inhibitors of SYK kinase

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Reexamination Certificate

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10413980

ABSTRACT:
Disclosed are compounds of formula (I):wherein R3, R5, R7and R8are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

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Cywin et al., Discovery & SAR of Novel [1,6Naphthyridines as Potent Inhibitors of Spleen Tyrosine Kinase (SYK), Bioorganic & Medicinal Chemistry Letters 13:1415-1418 (2003).
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