1-6-naphthyridine derivatives useful in the treatment of blood v

Details 1-6-naphthyridine derivatives useful in the treatment of blood v 1-6-naphthyridine derivatives useful in the treatment of blood v

1986-07-30

1987-12-08

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514212, 540597, 546123, A61K 3144, C07D47104

Patent

active

047119012

ABSTRACT:
The present invention describes 1,6-naphthyridine derivatives of the general formula: ##STR1## wherein R.sup.1 is an unsubstituted or substituted aromtic or heteroaromatic ring, R.sup.2 is a straight-chained or branched alkyl radical containing up to four carbon atoms or a benzyl radical, R.sup.3 is a hydrogen atom, a straight-chained or branched alkyl radical or an alkoxycarbonyl radical containing up to four carbon atoms, R.sup.4 is a straight-chained or branched alkyl radical containing up to four carbons and R.sup.5 is a carbonyl group or a straight-chained, branched or cyclic alkoxycarbonyl radical which contains up to 17 carbon atoms and optionally also contains an oxygen, sulphur or nitrogen atom; as well as the pharamacologically acceptable salts thereof, which are useful for treating diseases of the blood vessels.

REFERENCES:
patent: 4304914 (1981-08-01), Shroff et al.
Advances in Het. Chem., vol. 12, pp. 185-189 (1970).
Hopkins et al., J. Org. Chem., 32, pp. 4040-4044.
Schramm et al., Nature, vol. 303, pp. 535-537 (1983).

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