1-(6-Hydroxy-4- or -7-methoxy-5-benzofuranyl)-4-substituted-1,3-

Details 1-(6-Hydroxy-4- or -7-methoxy-5-benzofuranyl)-4-substituted-1,3- 1-(6-Hydroxy-4- or -7-methoxy-5-benzofuranyl)-4-substituted-1,3-

1982-07-30

1984-07-31

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

544153, 544376, 546196, C07D30786, C07D30778

Patent

active

044631855

ABSTRACT:
The present invention provides novel 1-(6-hydroxy-4- or 7-methoxy or 4,7-dimethoxy-5-benzofuranyl)-4-substituted-1,3-butanediones which are useful as intermediates in the synthesis of khellin and related anti-atherosclerotic furochromones.

REFERENCES:
patent: 2680119 (1954-06-01), Robertson et al.
patent: 4284569 (1981-08-01), Gammill
R. Aneja, et al., A New Synthesis of Khellin, J. Sci. Industr. Res., 17B:382-383 (1958).
R. Aneja, et al., Neue Synthesen von Khellin, Chem. Ber., 93:297-303 (1960).
R. A. Baxter, et al., Furochromones. Part I. The Synthesis of Khellin, J. Chem. Soc., pp. S30-S33 (1949).
J. R. Clarke, et al., Furano-compounds, Part IX, The Synthesis of Kellin and Related Compounds, J. Chem. Soc., pp. 302-307 (1949).
O. Dann, et al., Eine Neue Synthese von Khellin und Anderen Furo-2-Methyl-Chromonen, Ann. Chem. 605:146-157 (1957).
O. Dann, et al., Synthese von 2-Methyl-5.8-dihydroxy-furano-[3'.2':6.7]-Chromon und von Khellin, Chem. Berg., 93:2829-2833 (1960).
T. S. Gardner, et al., The Synthesis of Khellin Derivatives, J. Org. Chem., 15:841-849 (1950).
T. A. Geissman, et al., Chromones, III, A Total Synthesis of Khellin, J. Amer. Chem. Soc., 73:1280-1284 (1951).
V. V. S. Murti, et al., A Synthesis of Kellin, J. Sci. Ind. Res. (India) 8B:112-113 (1949).
V. V. S. Murti, et al., Nuclear Oxidation in Flavones and Related Compounds Part XXIII., Proc. of the Indian Acad. of Sci., 30A:107-113 (1949).
C. Musante, Prodotti di scissione alcalina della Khellina e loro derivati e trasformazione del sistema del furo-cromone in quello del furo-benzo-isossazolo, Gazz. Chim. Ital., 88:910-929 (1958).
A. Mustafa, Furopyrans and Furopyrones, Chapter III, Furochromones, John Wiley and Sons, Inc., New York, pp. 102-159 (1967).
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L. R. Row, et al., Furanobenzopyrones: Part VII, Indian J. Chem., 5:105-106 (1967).
A. Schonberg, et al., Khellin from Visnagin, J. Amer. Chem. Soc., 73:2960-2961 (1951).
E. Spath et al., Die Konstitution des Kellins, Chem. Ber., 71:106-113 (1938).

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