1,6-Dimesyl-3,4-dimethyl-D-mannitol and a process for the prepar

Details 1,6-Dimesyl-3,4-dimethyl-D-mannitol and a process for the prepar 1,6-Dimesyl-3,4-dimethyl-D-mannitol and a process for the prepar

1979-04-26

1980-11-25

Chan, Nicky

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424303, C07C14368

Patent

active

042358035

ABSTRACT:
The invention relates to 1,6-dimesyl-3,4-dimethyl-D-mannitol of the formula (I), ##STR1## wherein Ms is mesyl and Me is methyl. This compound is a potent cytostatic agent which can be used to advantage in the therapy of various tumorous diseases.
1,6-Dimesyl-3,4-dimethyl-D-mannitol is prepared according to the invention by subjecting 3,4-dimethyl-D-mannitol to partial mesylation followed by acylation, and splitting off the acyl groups of the resulting compound of the general formula (III), ##STR2## wherein Ms and Me are as defined above and R is a saturated lower aliphatic group, with an acidic alcohol.

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