Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1987-04-28
1988-07-26
Phillips, Delbert R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514807, 530315, A61K 3734, C07K 716
Patent
active
047600527
ABSTRACT:
New compounds which have potent V.sub.2 -vasopressin antagonistic activity are prepared by a 1,6-cyclization using peptide bond formation. The structures of the compounds are characterized by a Pas.sup.1,6 or Tas.sup.1,6 cyclized unit. Also a chiral synthesis of the optically pure Pas intermediates is described.
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Callahan James F.
Huffman William F.
Newlander Kenneth A.
Yim Nelson C. F.
Lourier Alan D.
Phillips Delbert R.
SmithKline Beckman Corporation
Suter Stuart R.
Williams Janice E.
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