1,6-Di-O-(2-isocyano-3-methylcrotonyl)-D-mannitol compounds

Details 1,6-Di-O-(2-isocyano-3-methylcrotonyl)-D-mannitol compounds 1,6-Di-O-(2-isocyano-3-methylcrotonyl)-D-mannitol compounds

1972-07-18

1976-09-07

Brust, Joseph Paul

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

195 81, 424304, C07C12138, C12D 900

Patent

active

039794334

ABSTRACT:
Antibiotic A-32390 complex, comprising factor A and other structurally related factors, is produced by cultivation of Pyrenochaeta sp. NRRL 5786 under submerged aerobic conditions, and isolated by extraction of the broth. Individual A-32390 factor A is separated by chromatography. The A-32390 complex, individual factor A and acyl ester derivatives of factor A inhibit dopamine-.beta.-hydroxylase and have antifungal, antibacterial, and hypotensive activity.

REFERENCES:
patent: 3419596 (1968-12-01), Fetzer et al.
patent: 3636036 (1972-01-01), Ugi
patent: 3712911 (1973-01-01), Schoellkopf et al.

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