1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids

Details 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids 1-, 6- And 2-substituted-1-carba-2-penem-3-carboxylic acids

1978-10-24

1981-04-07

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fungus, except allergen, or component thereof or substance...

260239A, 2602452T, 424250, 424263, 424269, 424270, 424273P, 424273N, 542453, 544 90, 544333, 546272, C07D48704, A61K 3140

Patent

active

042606276

ABSTRACT:
Disclosed are 1-, 6- and 2-substituted-1-carba-2-penem-3-carboxylic acids of the following structure: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are, inter alia, independently selected from the group consisting of hydrogen, alkyl, aryl, and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.

REFERENCES:
patent: 3950357 (1976-04-01), Kahan

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