1,5-heterocyclic metalloprotease inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514221, 540487, 540492, 540500, 540502, 540503, 540504, 540506, 540507, 540508, 540509, 540510, 540542, 540543, 540567, 540568, 540569, 540570, 540572, 540573, 540575, A61K 31551, C07D24308

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06121258&

ABSTRACT:
The invention provides compounds of formula ##STR1## as described in the claims, or an optical isomer, diastereomer or enantiomer thereof, or a pharmaceutically-acceptable salt, or biohydrolyzable amide, ester, or imide thereof are useful as inhibitors of metalloproteases.
Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by metalloprotease activity using these compounds or the pharmaceutical compositions containing them.

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Chapman, K.T., et al., "Inhibition of Matrix Metalloproteinases by N-Carboxyalkyl Peptides", Journal of Medicinal Chemistry, vol. 36 (1993), pp. 4293-4301.
Johnson, w.K., Roberts, N.a., and Borkakoti, N., "Collagenase Inhibitors: Their Design and Potential Therapeutic Use", Journal of Enzyme Inhibition, vol. 2 (1987), pp. 1-22.
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Singh, J., et al. "Relationship Between Structure and Bioavailability in a Series of Hydroxamate Based metalloprotease Inhibitors", Bioorganic & Medicinal Chemistry Letters, vol. 5 (1995), pp. 337-342.
Tomczuk, B.E., et al., "Hydroxamate Inhibitors of the Matrix Metallo-Proteinases (MMPs) containing Novel P.sub.1 ' Heteroatom Based Modifications", bioorganic & Medicinal chemistry Letters, vol. 5 (1995), pp. 343-348.
Turbanti, L., et al., "1,2-Cyclomethylenecarboxylic Monoamide Hydroxamic Derivatives. A Novel Class of Non-amino Acid Angiotensin Converting Enzyme Inhibitors", Journal of Medicinal Chemistry, vol. 36 (1993), pp. 699-707.
Galardy et al., Inhibition of Angiogenesis by the Matrix Metalloprotease Inhibitor N-[2R-2-(Hydroxamidocarbonylmethyl)-4-methylpentanoyl)]-L-tryptophan Methylamide, Cancer Research, vol. 54, No. 17, pp. 4715-4718, Sep. 1, 1994 .

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