1,5-diphenyl pyrazole compounds for treatment of inflammation

Details 1,5-diphenyl pyrazole compounds for treatment of inflammation 1,5-diphenyl pyrazole compounds for treatment of inflammation

1993-11-30

1995-12-12

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483771, A61K 31415, C07D23112

Patent

active

054750180

ABSTRACT:
A class of 1,5-diphenyl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I ##STR1## wherein R.sup.1 is methylsulfonyl; wherein R.sup.2 is selected from --CF.sub.3, --CF.sub.2 Cl, --CF.sub.2 H, --CF.sub.2 CF.sub.3 and --CF.sub.2 CF.sub.2 CF.sub.3 ; and wherein R.sup.3 is fluoro or chloro; or a pharmaceutically-acceptable salt thereof.

REFERENCES:
patent: 4146721 (1979-03-01), Rainer
patent: 4914121 (1990-04-01), Sawai et al.
patent: 5051518 (1991-09-01), Murray et al.
patent: 5134142 (1992-07-01), Matsuo et al.
patent: 5164381 (1992-11-01), Wachter et al.
patent: 5298521 (1994-03-01), Ferro

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