1,5-diphenyl-3-pyridinylamino-1,5-dihydropyrrolidin-2-one as...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S278400

Reexamination Certificate

active

07998985

ABSTRACT:
Compound and pharmaceutical compositions comprising the compounds of the Formulaor a pharmaceutically acceptable salt thereof, as a CB1receptor inverse agonist, useful for reducing body weight in mammals, treating cognitive impairment associated with schizophrenia, and mitigating treatment emergent weight gain observed during treatment with antipsychotics.

REFERENCES:
patent: WO 2005/077911 (2005-08-01), None
patent: WO 2005/080345 (2005-09-01), None
patent: WO 2007/020502 (2007-02-01), None
Piomelli, et al., “Review—The endocannabinoid system as a target for therapeutic drugs”,TIPS—vol. 21-218-224 (2000).
Goya, et al., “Recent advances in cannabinoid receptor agonists and antagonists”Exp. Opin. Ther. Patentsvol. 10 (10), 1529-1538 (2000).
Xiang, et al., “Pharamacology of Cannabinoid Receptor Agonists and Antagonists”.Annual Report in Medicinal Chemistry—Academic Press, NY—vol. 34. 199-208.
Francis Barth, “Cannabinoid receptor agonists and antagonists”,Expert Opinion on Therapeutic Patents—vol. 8(3) 301-313 (1998).
Andreichikov, et al. “Five membered 2,3-dioxo heterocycles, I. Synthesis and structure of 1,5-d”,Zhurnal Organicheskoi Khimii—22(10) 2208-13 (1986).

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