1,5-benzothiazepine derivatives and their pharmaceutical use

Details 1,5-benzothiazepine derivatives and their pharmaceutical use 1,5-benzothiazepine derivatives and their pharmaceutical use

1985-02-04

1986-05-20

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602393B, A61K 3155, C07D28110

Patent

active

045901880

ABSTRACT:
Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R.sup.1 is lower alkyl or lower alkoxy, R.sup.2 is hydrogen atom or lower alkanoyl, each one of R.sup.3 and R.sup.4 is lower alkyl, Ring A is a substituted benzene ring of the formula: ##STR2## R.sup.a is lower alkyl, lower alkoxy, lower alkylthio or benzyloxy, each one of R.sup.b and R.sup.c is lower alkyl, lower alkoxy or halogen atom, and either one of R.sup.d and R.sup.e is fluorine atom and the other one is hydrogen atom, or a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt are useful as a hypotensive agent and/or a cerebral or coronary vasodilator.

REFERENCES:
patent: 3075967 (1963-01-01), Krapcho
patent: 3309361 (1967-03-01), Krapcho et al.
patent: 3341516 (1967-09-01), Krapcho
patent: 3562257 (1971-02-01), Kugita et al.

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