1,5-benzothiazepine derivatives and processes for preparing the

Details 1,5-benzothiazepine derivatives and processes for preparing the 1,5-benzothiazepine derivatives and processes for preparing the

1985-03-22

1986-04-29

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

2602393B, A61K 3155, C07D28110

Patent

active

045857687

ABSTRACT:
Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein R.sup.1 is hydrogen or lower alkyl, R.sup.2 is hydrogen, lower alkanoyl or benzyl, R.sup.3 is hydrogen or lower alkyl and either one of R.sup.4 and R.sup.5 is hydrogen and the other is chlorine, or a pharmaceutically acceptable acid addition salt thereof are disclosed. Said derivative (I) and its salt have a potent platelet aggregation-inhibiting activity.

REFERENCES:
patent: 3075967 (1963-01-01), Krapcho
patent: 3341519 (1967-09-01), Krapcho
patent: 3562257 (1971-02-01), Kugita et al.
Murphy et al. "Proceedings National Academy of Sciences (USA)" (1983) vol. 80, No. 3, pp. 860-864.
"Circulation Research Supp. I.," Calcium Channel-Blocking Drugs, vol. 52, pp. I-115-I-119, 1983 (Kiyomoto, et al.).

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