1,5-benzothiazepine derivatives and preparation thereof

Details 1,5-benzothiazepine derivatives and preparation thereof 1,5-benzothiazepine derivatives and preparation thereof

1990-08-21

1992-07-28

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540491, C07D28110, A61K 3155

Patent

active

051341395

ABSTRACT:
Novel 1,5-benzothiazepine derivatives of the formula: ##STR1## wherein X is hydrogen atom, a halogen atom or a lower alkyl group; R.sup.1 is a lower alkyl group or a lower alkoxy group; R.sup.2 is hydrogen atom, a lower alkyl group, a substituted or unsubstituted phenyl group, a substituted or unsubstituted phenyl-lower alkyl grup or a diphenyl-lower alkyl group; R.sup.3 is a lower alkyl group or a substituted or unsubstituted phenyl-lower alkyl group, Q is single bond, or an alkylene or lower alkenylene group which may optionally be substituted by a lower alkoxy group or oxo group; R.sup.4 is (i) hydrogen atom, (ii) a lower alkyl group, (iii) an N-phenyl-N-lower alkylamino group, (iv) a phenyl, phenyloxy, phenylthio, benzenesulfonylamino, 1,4-benzoquinonyl or benzylthio group which may optionally have substituent, or (v) a heterocyclic group which may optionally have substituent; and n is 2 or 3, or a pharmaceutically acceptable salt thereof, which are useful as a calcium antagonist, and the process for preparing thereof.

REFERENCES:
patent: 3562257 (1971-02-01), Kugita et al.
patent: 4729994 (1988-03-01), Carson
Inoue, Chem. Abs., 110, 231671 (1988).
Inoue, Chemical Abstracts, 110:231671a, p. 653, vol. 110, No. 25 (Jun. 1989).

Affiliated with

Also associated with

Rating

1,5-benzothiazepine derivatives and preparation thereof does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,5-benzothiazepine derivatives and preparation thereof, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,5-benzothiazepine derivatives and preparation thereof will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1687205