1,5-Benzodiazocines

Details 1,5-Benzodiazocines 1,5-Benzodiazocines

1975-10-15

1978-05-16

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260239BD, 2602948C, 2602949, 260296B, 2603472, 2603477, 424263, 424285, A61K 3144, A61K 31395, C07D24506, C07D40104

Patent

active

040899535

ABSTRACT:
1,5-Benzodiazocines of the general formula ##STR1## their 5N-oxides, and acid addition salts thereof. In the above formula R.sub.1 =H, Halogen, CF.sub.3, --CN, --NO, C.sub.1-6 alkyl, C.sub.1-6 alkoxy or C.sub.1-6 alkylthio; R.sub.2 =H, C.sub.1-6 alkyl or furyl; R.sub.3 =H, C.sub.1-6 alkyl, hydroxy-(C.sub.1-6 alkyl), C.sub.2-6 alkenyl or benzyl; and R.sub.4 =phenyl, (C.sub.1-6 alkyl)-phenyl, nitrophenyl, halophenyl or pyridyl. Also the production of such compounds from compounds of the benzodiazepine series.

REFERENCES:
patent: 3398159 (1968-08-01), Berger et al.
patent: 3442946 (1969-05-01), Keller et al.
patent: 3466328 (1969-09-01), Berger et al.
patent: 3523939 (1970-08-01), Fryer et al.
patent: 3751412 (1973-08-01), Natsugari et al.
Kuwada et al., Chem. Abstracts, vol. 79, Abstract No. 78860f, (1973).
Kuwada et al., Chem. Abstracts, vol. 80, Abstract No. 96049y, (1974).
Kuwada et al., Chem. Abstracts, vol. 81, Abstract No. 37586u, (1974).
Greenblatt et al., Benzodiazepines in Clinical Practice, (Raven Press, N. Y., 1974), pp. 10-13, 43-44.
Gordon, Psychopharmacological Agents, vol. I, (Academic Press, N.Y., 1964), p. 5.

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