1-[5-(3,4,5-Trimethoxy phenyl)-2,4-pentadienoyl]-4-(substituted

Details 1-[5-(3,4,5-Trimethoxy phenyl)-2,4-pentadienoyl]-4-(substituted 1-[5-(3,4,5-Trimethoxy phenyl)-2,4-pentadienoyl]-4-(substituted

1985-09-16

1987-04-07

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544372, 544391, A61K 31505, C07D40300

Patent

active

046561722

ABSTRACT:
There are disclosed novel piperazine derivatives and vasodilators containing the same. The compounds are useful for controlling or preventing vascular disorders such as cerebral embolism, myocardial infarction and limb arterial obstruction. As typical compounds are mentioned 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(pyrrolidinocarbonylmeth yl)-piperazine, 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(N-isopropylaminocarbony lmethyl)-piperazine, 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(N,N-dimethylaminocarbon ylmethyl)piperazine and 1-[5-(3,4,5-trimethoxyphenyl)-2,4-pentadienoyl]-4-(methylaminocarbonylmeth yl)-piperazine.

REFERENCES:
patent: 3407199 (1968-10-01), Pachter
patent: 3410857 (1968-11-01), Schoen et al.
patent: 3634411 (1972-01-01), Faurau et al.
patent: 4029650 (1977-06-01), Raymond et al.
Chemical Abstracts, vol. 88, No. 19, May 8, 1978, p. 503, No. 136267s, B. Vig et al., "Synthesis of Analogs of G-Phenylpenta-Trans-2, Trans-4-Dienoic Acid Amide" & Indian J. Chem., Sect. B 1977, 15B(11), 1048-1049.

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