Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reissue Patent
2007-06-05
2007-06-05
Powers, Fiona T. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S403000, C546S275400, C548S364400, C548S365700, C548S379100, C548S379700
Reissue Patent
active
10630397
ABSTRACT:
Compounds of the formulawherein:X is selected from the group consisting of trihalomethyl, C1-C6alkyl, and a group of formula II:wherein:R3and R4are independently selected from the group consisting of hydrogen; halogen; hydroxyl; nitro; C1-C6alkyl;C1-C6alkoxy; carboxy; C1-C6trihaloalkyl; and cyano;Z is selected from the group consisting of substituted and unsubstituted aryl; or a pharmaceutically acceptable salt thereof. The compounds are inhibitors of cyclooxygenase-2 activity. They are useful for treating cyclooxygenase-mediated disorders, including, for example, inflamation, neoplastic disorders and angiogenesis-mediated disorders.
REFERENCES:
patent: 2640056 (1953-05-01), Kendall et al.
patent: 2740793 (1956-04-01), Kendall et al.
patent: 3836523 (1974-09-01), Turner
patent: 3865816 (1975-02-01), Mengler
patent: 3980795 (1976-09-01), Gante et al.
patent: 4045571 (1977-08-01), Möller et al.
patent: 4407803 (1983-10-01), Haviv et al.
patent: 4447442 (1984-05-01), Dusza et al.
patent: 4448973 (1984-05-01), Dusza et al.
patent: 4968687 (1990-11-01), Findeisen et al.
patent: 5134148 (1992-07-01), Crawley et al.
patent: 5300522 (1994-04-01), Klaus et al.
patent: 5334719 (1994-08-01), Frenette
patent: 5403838 (1995-04-01), Kirstgen et al.
patent: 5434178 (1995-07-01), Talley et al.
patent: 5700816 (1997-12-01), Isakson et al.
patent: 5756529 (1998-05-01), Isakson et al.
patent: 5908852 (1999-06-01), Talley et al.
patent: 5972986 (1999-10-01), Seibert et al.
patent: 6025353 (2000-02-01), Masferrer et al.
patent: WO 98/56377 (1998-12-01), None
patent: WO 99/32884 (1999-12-01), None
patent: WO 99/62884 (1999-12-01), None
Golub et al., Science, 286, 531-537, 1999.
Database CAS online on STN (Columbus, Ohio) AN 1992:591744, doc. No. 117:191744, Faidallah et al., Pak. J. Sci. Ind. Res. (1992) 35(1-2), 8-13.
Cuberes-Altisent et al., “Diarylpyrazoles as Inhibitors of Cyclooxygenase-2”, Database CAS online on STN (Columbus, Ohio) AN 199:78401, Doc. No. 132:12302, WO 99/62884, Dec. 12, 1999.
H.M. Faidallah et al., “Trisubstituted Pyrazoles of Possible Hypoglycemic Activity”,Pak. j. sci. ind. res., vol. 35, Nos. 1-2, Jan.-Feb. 1992, pp. 8-13.
Makki et al., Chemical Abstracts, 121:134017, 1994.
M. M. El Sadek et al., “Synthesis and Spectral Studies of Some New Pyrazolines and Pyrazoles”,Egypt J. Chem., 38, No. 4, pp. 403-418 (1995).
Thomas D. Penning et al., “Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)”,J. Med. Chem.1997, 40, 1347-1365.
Hassan M. Feid-Allah et al., “Trisubstituted Pyrazoles of Possible Antidiabetic and Antibacterial Activity”, Pharmazie 36, H. I I (1981), pp. 754-756.
Hassan M. Faid-Allah, et al., “Pyrazole Derivatives with Possible Hypoglycemic Activity”,Indian Journal of Chemistry, vol. 27B Mar. 1998, pp. 245-249.
Raafat Soliman et al., “Preparation and Antidlabetic Activity of New Substituted 3,5-Diarylpyrazolesulfonylurea Derivatives II: Structure-Activity Relationship”,Journal of Pharmaceutical Sciences, vol. 76, No. 8, Aug. 1997, p. 626-632.
Salem A. Basail et al., “Synthesis and Biological Activity of New Pyrazolines and Pyrazoles”,Indian Journal of Heterocyclic Chemistry, vol. 6, Jul.-Sep. 1996, pp. 53-58.
Hassan M. Mokhtar, “Synthesis of Trisubstituted Pyrazoles with Possible Antimicrobial Activity”,Pakistan J. Sci. Ind. Res., vol. 28, No. 1, Apr. 1985, pp. 85-91.
Atonio Bellotti, “Ricerche nella serie pirazolinica. —Nota 1, Sintesi di alcune 5-(2-furil)-pirazoline”, Ann. Chim. (Rome), vol. 50, 1960, pp. 1074-1083.
Hassan M. Faidallah et al., “Triazole-Pyrazole Compounds with Possible Biological Activity”,Part-I. Synthesis and Spectra,Pak j. sci. ind. res., vol. 35, No. 6, Jun. 1992, pp. 213-220.
Hassan M. Mokhtar et al, “Triazole-Pyrazole Compounds with Possible Biological Activity”,Part-II, Pak. j. sci. ind. res., vol. 35, No. 11, Nov. 1992, pp. 428-433.
Reddy E. Premkumar
Reddy M. V. Ramana
Drinker Biddle & Reath LLP
Monaco Daniel A.
Powers Fiona T.
Temple University - of the Commonwealth System of Higher Educati
LandOfFree
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