1,4-naphthalenediol and 1,4-hydroquinone derivatives

Details 1,4-naphthalenediol and 1,4-hydroquinone derivatives 1,4-naphthalenediol and 1,4-hydroquinone derivatives

1989-03-13

1990-07-03

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514460, 514548, 514546, 549416, 560139, 560134, 560 28, 560 25, A61K 3135, A61K 3122, C07C12507, C07D30912

Patent

active

049391690

ABSTRACT:
Novel 1,4-naphthalenediol and 1,4-hydroquinone derivatives of formula I, II, III and IV and their therapeutic uses as 5-lipoxygenase inhibitors, leukotriene inhibitors, antiinflammatory and/or inhibitors of mucus secretion agents are described. Also provided are novel intermediates useful for the preparation of said derivatives. ##STR1##

REFERENCES:
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patent: 4388312 (1983-06-01), Terao et al.
patent: 4407757 (1983-10-01), Morimoto et al.
patent: 4833164 (1989-05-01), Batt
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T. Yoshimoto et al., 2,3,5-Trimethyl-6-(12-Hydroxy-5,10-Dodecadiynyl)-1,4-Benzoquinone (AA861), A Selective Inhibitor of the 5-Lipoxygenase Reaction and the Biosynthesis of Slow-Reacting Substance of Anaphylaxis, Biochim. Biophys. Acta., 713: 470-473 (1982).
Y. Ashida et al., Pharmacological Profile of AA-861, A 5-Lipoxygenase Inhibitor, Prostaglandins 26 (No. 6): 955-972 (1983).
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Chemical Abstracts, vol. 99, No. 9, 29 Aug. 1983, K. H. Doetz et al.: "Reactions of Complexing Ligands, XXIV, Synthesis of Naphthol Derivatives from Carbonylcarbene Complexes and Alkynes: Regioselsective Incorporation of the Alkyne to the Naphthalene Framework", see p. 644, Abstract No. 70913t.
Chemical Abstracts, vol. 63, No. 10, 8 Nov. 1965, O. Goncalves de Lima et al.: "Antibiotic Behavior of Compounds Related to the Synthesis of 7-Methoxy-3,9-Dimethyl-1-Oxaphenalene", see col. 13869d.

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