1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone and...

Details 1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone and... 1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone and...

2006-05-23

2006-05-23

Tsang, Cecilia J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S105000, C549S302000, C549S326000, C568S308000, C568S331000

Reexamination Certificate

active

07049459

ABSTRACT:
This invention relates to 1-[(4-methyl thio)phenyl]-2-(phenyl acetoxy)-1-ethanone. This compound is convertible into 4-(4-methyl thio phenyl)-3-phenyl-2 (5H)-furanone by an economically viable process. This substituted furanone is an intermediate or starting compound for synthesising COX II inhibitor Rofecoxib. This invention also includes a process for preparing the ethanone derivative by halogenating methyl thio aceto phenone and coupling the resulting 2 halosubstituted ethanone with sodium salt of phenyl acetic acid to obtain 1-[(4-methyl thio) phenyl]-2-(phenyl acetoxy)-1-ethanone.

REFERENCES:
patent: WO98/00416 (1998-01-01), None

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