1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates

Details 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates

1973-08-06

1976-01-13

Daus, Donald G.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260268TR, 260283R, 260286R, 260289R, 424250, C07D29512

Patent

active

039324125

ABSTRACT:
Disclosed are compounds of the class of isoquinolines substituted at the 1-position by an amino function bearing a hydroxy-alkyl nitrate moiety, e.g., 1-(5-hydroxypentyl)-amino-6,7-methylene-dioxyisoquinoline nitrate. The compounds have various pharmacological activities in animals and are useful, for example, as anti-hypertensive agents, anti-anginal agents and in the treatment of shock. Also disclosed are the corresponding hydroxy intermediates which are useful in preparation of the nitrates and also as hypotensive agents or as agents in the treatment of shock.

REFERENCES:
patent: 3511836 (1970-05-01), Hess
patent: 3517005 (1970-06-01), Cronin et al.
patent: 3637699 (1972-01-01), Gabel et al.
patent: 3637700 (1972-01-01), Gabel et al.
patent: 3637701 (1972-01-01), Gabel et al.
patent: 3778440 (1973-12-01), Simpson

Affiliated with

Also associated with

Rating

1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1-(4-Hydroxyalkylpiperazino)-isoquinoline nitrates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-746498