1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and com

Details 1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and com 1,4-Dithiin (and oxathiin)-yl cephalosporin derivatives, and com

1975-09-26

1977-06-14

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

260243C, 260327P, 260468J, C07D50122, C07D50134, A61K 3154

Patent

active

040297810

ABSTRACT:
New cephalosporin compounds of the formula: ##STR1## in which A is oxygen or sulphur, R.sub.1 is hydrogen or acetoxy and R.sub.2 is carboxy or a radical of the formula: ##STR2## in which the radical ##STR3## is a radical which can be easily removed enzymatically, and in which R.sub.3 is hydrogen or straight or branched chain C.sub.1-4 alkyl and R.sub.4 is straight or branched chain C.sub.1-4, alkyl or cyclohexyl, together with its diastereoisomeric forms and mixtures thereof, its acid addition salts and, where appropriate, its pharmaceutically acceptable non-toxic metal salts and addition salts with nitrogen-containing bases other than ammonia, exhibit valuable anti-bacterial properties, in particular against Gram-positive and Gram-negative bacteria.

REFERENCES:
patent: 3516997 (1970-06-01), Takano et al.
patent: 3692779 (1972-09-01), Holdrege
patent: 3886151 (1975-05-01), Wei
patent: 3891629 (1975-06-01), Diassi et al.

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