1,4-disubstituted pyrazole derivatives, compositions and use

Details 1,4-disubstituted pyrazole derivatives, compositions and use 1,4-disubstituted pyrazole derivatives, compositions and use

1988-11-15

1989-07-25

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

5142362, 514316, 514326, 514362, 544 82, 544134, 546187, 546211, 548135, A61K 31425, A61K 31535, C07D41712, C07D41714

Patent

active

048514101

ABSTRACT:
1,4-disubstituted pyrazole derivatives of the formula I ##STR1## where R.sup.1 and R.sup.2 independently of one another are each hydrogen, lower alkyl or benzyl, or R.sup.1 and R.sup.2, together with the nitrogen atom to which they are bonded, may be a pyrrolidino, piperidino or morpholino radical, n is an integer from 2 to 5 and Z is a radical of the formula ##STR2## or QNR.sup.1 R.sup.2 where R.sup.1 and R.sup.2 have the same meanings as above, Q is ##STR3## A is CHR.sup.3 or NR.sup.3 in which R.sup.3 is CN, NO.sub.2, SO.sub.2 -aryl or SO.sub.2 -lower alkyl and m may be 0 or 1, and their pharmaceutically tolerated salts, processes for their preparation, pharmaceutical compositions containing the compounds of formula I, the use of such compositions and an intermediate of the formula III ##STR4## where R.sup.1, R.sup.2 and n have the same meanings as above, in the preparation of the compounds of the formula I.
The compounds are useful to block histamine H.sub.2.sup.- receptors.

REFERENCES:
patent: 4330544 (1982-05-01), Jarreau et al.
patent: 4374248 (1983-02-01), Crenshaw et al.
patent: 4447441 (1984-05-01), Yellin et al.
patent: 4464374 (1984-08-01), Yellin et al.
patent: 4639519 (1987-01-01), Ganellin et al.
patent: 4659721 (1987-04-01), Schickaneder et al.
Chem. Abst. vol. 99, No. 1, pp. 1 and 185, col. 2, No. 1737b (1983).

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