1,4-disubstituted piperazines, pharmaceutical compositions there

Details 1,4-disubstituted piperazines, pharmaceutical compositions there 1,4-disubstituted piperazines, pharmaceutical compositions there

1987-04-22

1989-09-12

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544397, A61K 31495, C07D29508

Patent

active

048660620

ABSTRACT:
The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation.
In the general formula (I) ##STR1## R.sub.1 and R.sub.2 are the same or different and stand for hydrogen or halogen or a lower alkyl, trihalomethyl or lower alkoxy group.
The compounds of the general formula (I) are therapeutically useful for the treatment of diseases arising from a hypofunction of the dopaminergic system.

REFERENCES:
patent: 2988551 (1961-06-01), Morren
patent: 4202896 (1980-05-01), Gootjes
Morren, 1,4-Bis(2-Trydroxyethyl)Piperazine Derivatives CA vol. 56, 4778d (1962) e.g. US 2988551.
Hohensee, the Pharmacological Action of Some Basic Esters CA. vol. 50, 4405b (1956).
Riffkin et al., Syntheses of Amino Ethers with Potential Pharmacological Activity, CA. vol. 50, 16792d (1956).
Morren et al., New 1,4-Disubstituted Derivatives of Piperazine and Their Antihistaminic Properties, CA. vol. 53, 2240e (1959).
Morren, Piperazine Derivatives, CA. vol. 53, 17156i (1959) e.g. Bel. 530795-530797.
Carlsson (1988) Perspectives in Psychopharmacology Collection of Papers in Honor of E. Usdin. Alan L. Riss, Inc., pp. 209-233.
Gottries (1985) Psychopharmacology 86:245-252.

Affiliated with

Also associated with

Rating

1,4-disubstituted piperazines, pharmaceutical compositions there does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,4-disubstituted piperazines, pharmaceutical compositions there, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,4-disubstituted piperazines, pharmaceutical compositions there will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-916443