1,4-Disubstituted piperazines having dopaminergic activity

Details 1,4-Disubstituted piperazines having dopaminergic activity 1,4-Disubstituted piperazines having dopaminergic activity

1987-04-22

1989-10-17

Shen, Cecilia

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544386, 544397, A61K 31495, C07D29508, C07D29510

Patent

active

048747653

ABSTRACT:
The invention relates to novel 1,4-disubstituted piperazine derivatives of the general formula (I), pharmaceutically acceptable acid addition and quaternary ammonium salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the general formula (I) ##STR1## R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and stand for hydrogen or halogen or a trihalomethyl, lower alkyl, lower alkoxy, nitro, hydroxyl, aralkyloxy or an 1-(2-propenyl-4-piperazinyl) group;

REFERENCES:
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Vadodaria et al., Synthesis and Central Nervous System Depressant Activity of New Piperazine Derivatives and Related Compounds, CA vol. 71, 1969, 101817t.
Patel et al., Antimicrobial Activity of Piperazine Derivatives and Related Compounds.
Melon et al., 1,4-disubstituted piperazine derivatives eq. Fr. 2,276,824, CA: vol. 85, 1976, 160163p.
Gist-Brocades, Piperazine Derivatives; and Pharmaceutical Comp. Containing Them. CA, vol. 100, 1984, 191909u.
Carlsson (1988) Perspectives in Psychopharmacology Collection of Papers in Honor of E. Usdin. Alan L. Riss, Inc. pp. 209-223.
Gottries (1985) Psychopharmacology 86:245-252.
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